I don't read a lot of comic books, so my knowledge of the Hulk is limited to the animated world and movies. I turn to my buddy, who is a comics nut, and he tells me that Hulk absolutely can regenerate
, though usually he never has to (its near impossible to inflict wounds on him large enough that he has to regenerate).
My buddy also plays M&M, and he also said he'd absolutely NOT
allow Hulk to have a huge (17+) Toughness and also have large ranks of regenerate. I kind of agree; for the sake of actually being able to challenge the Hulk, I think some of his iconic powers have to slide (including his iconic power of being the STRONGEST EFFING THING IN THE ENTIRE UNIVERSE). If Hulk ever does get hurt enough to have to heal up, he can always Power Stunt a Self Heal (and Self Heal is way more effective than Regeneration, IMO).
I don't mind if you take 3e Impervious, or if Kevin allows, one of the variants in the Armor Power Profiles. Half-Effect Immunities are also fine, because they are expensive enough to actually appropriately match the level of utility.
Another option is simply not
use all those extra points. If the build has everything you need, just put it down and back away.
M&M can't handle too much optimization, its not D&D.