So a cosmic based Marvel Universe setting used M & M 2e?
Hmm, i can probably run it, i actually run my own setting which is a mix of Marvel, DC, and Freedom City, with some original twists.
Although i don't think i would be very comfortable using any of the programs you have mentioned.
If there was a way to create a java based chat window that we could use it would be better.
Let me know, also i'm thinking of using the standard PL 10 as starting level, if you decide i'd make a good GM