Brain:PL:10
Str n/a (--) Dex 10 (+0) Con n/a (--) Int 22 (+6) Wis 22 (+6) Cha 14 (+2)
Skills: Bluff 8 (+10), Craft (Chemical) 8 (+14), Craft (Electronic) 8 (+14), Craft (Mechanical) 8 (+14), Computers 8 (+14), Diplomacy 8 (+10), Intimidate 8 (+10), Knowledge (Physical Sciences) 8 (+14), Knowledge (Tactics) 8 (+14), Knowledge (Technology) 8 (+14), Notice 8 (+14), Sense Motive 8 (+14)
Feats: Assessment, Attack Spec. (Laser Blaster) 4, Challenges 2 (Forceful Intimidation; Quick Planning), Connected, Contacts, Eidetic Memory, Equipment 15, Master Plan, Minions 8, Skill Mastery (Bluf; Intimidate; Knowledge {Physical Sciences}; {Technology}), Well-Informed
Powers: Blast 10 [laser blaster] (Extra: Penetrating)
Datalink 6
Immunity 30 (Fortitude Effects)
Protection 10 (Extra: Impervious)
Super-Movement 2 (Sure-Footed)
Saves: Toughness +10* [*Impervious]
Fort +n/a
Ref +0
Will +12
Combat: Attack +0/+8 (blaster)
Damage +10 (laser blaster)
Defense +8 (+4 flat-footed)
Initiative +0
Equipment: Base: [75 ep to build 2-3 bases]
Minions: [100 2nd level operatives]
Costs: Attributes 28+ Skills 24+ Feats 36+ Powers 90+ Saves 6+ Combat 16= 200 pts. 
Now for one of the original "Brain in a Jar" type of villains, the Brain.

To me the Brain is a pretty muc a pure mastermind, especially since he has no body with arms and such to be much use in a fight. However his effective planning and genius level intelligence allow him to compete in the world of heroes rather well, especially with the Brotherhood of Evil doing his dirty work.

Now honestly this build isn't 100% true to the Brain as he is in comics, it contains a dash or two of things from his showings in the Teen Titans show. Some of the elements used for him on it really made alot of sense to me, like having multiple bases, hordes of goons to do various jobs around the base (
guards of course, but also scientists building his various designs and such as well).

I like how he turned out though, this way he can sit back at his base and oversee the Brotherhood's current mission (
which he developed of course ) as well as the other plans he has going on at that time as it's been clearly shown that he runs several different plans at any given time.

I did think it was a good idea to at least give the Brain one option for protecting himself since it seems he no longer has Mallah with him to act as bodyguard. So I tossed in a simple laser blaster into his brain tank, nothing too fancy just some penetrating to show that he isn't a foe to be taken lightly.